David de Gea: An illness to Anders Lindegaard will rule him out of any late season minutes at the weekend.
Phil Jones: With Rafael still seemingly absent, expect Jones to continue at right-back.
Rio Ferdinand: Ryan Giggs may continue to trust the old guard this weekend with Jones at right-back and Evans not quite 100% fit.
Nemanja Vidic: United’s Serbian captain will probably partner Ferdinand but both may give way in midweek for Smalling and Evans.
Patrice Evra: Despite some OK performances of late from Alex Buttner, Evra is still United’s first choice at left-back.
Michael Carrick – Expect Giggs to trust Carrick at the base of midfield again on Saturday afternoon.
Tom Cleverley – A dynamic, if only mildly effective, performance from Cleverley last weekend may ensure he starts again this weekend as he looks to stake a late claim for a World Cup place.
Shinji Kagawa – Kagawa may start on the left once again offering the chance to link-up with Mata in the middle as the pair have done to good effect in the league recently.
Juan Mata – An impressive substitute’s showing from Mata last week should earn him a spot in Saturday’s starting XI.
Danny Welbeck – With Wayne Rooney looking doubtful and Robin van Persie perhaps not quite ready enough, Welbeck should be entrusted to lead the line alone against Sunderland.
United’s line-up will largely depend on the fitness of key players Rooney, Van Persie, Rafael and Evans.
However, it is likely that Giggs will stick with a similar starting XI to last weekend’s routing over Norwich with Mata the only change for Rooney.