David de Gea – Absolute no brainer.
Rafael – Rafael is set to remain the only defender in the same position from last weekend.
Tom Thorpe – Hard to pick Rojo’s partner but we’ve gone for 21-year-old Thorpe, although it could well be 19-year-old Paddy McNair.
Marcus Rojo – United’s only fit centre-back so he’ll certainly start.
Luke Shaw – Shaw should get his first United competitive start with so many out through injury.
Daley Blind – Blind will be essential in dropping back and providing good defensive cover in the absence of three senior centre-backs.
Ander Herrera – The Spaniard will need to put in another tough shift in midfield to compensate for United’s weakened back line.
Angel di Maria – Di Maria perhaps remains not quite fully fit but his quality is essential to United at the present time.
Radamel Falcao – Falcao is another still in the process of building fitness but 70 minutes a week ago will help his cause.
Robin van Persie – It would be a surprise to see the Dutchman dropped, but he needs to improve on recent performances to keep his striker position.