Manchester United: De Gea; Darmian, Blind, Smalling, Rojo; Schneiderlin, Schweinsteiger; Herrera, Mata, Martial; Rooney
Subs: Romero, Tuanzebe, Young, Carrick, Lingard, Pereira, Fellaini
Tuanzebe has impressed at U18 level for Man United and van Gaal has rewarded him with a place in the squad as Phil Jones is not included altogether.
Meanwhile, Wayne Rooney retains his place in the starting XI despite his poor form in recent weeks.
Palace will provide a stern test at Selhurst Park and United will need to be in top form if they are to secure a positive result. Van Gaal will be keen for his side to bounce back with a good performance following recent disappointments against Middlesbrough and Manchester City.