Borthwick-Jackson performed well against Liverpool last time out and his rapid progression into the first team should continue against Southampton on Saturday:
Elsewhere, Marouane Fellaini will likely line up in the middle of the park once again as Bastian Schweinsteiger is still out injured.
Fellaini provided the pivotal assist for Wayne Rooney’s winner against Liverpool but he was otherwise ineffectual in a deep midfield role.
The other option would be to move Ander Herrera deeper but the Spaniard has proven to be far more dangerous at No.10. It is crucial that United build up a head of steam after the result against Liverpool but they will have to do it with a threadbare squad.