Darmian picked up a complaint in the 1-0 loss against Southampton last time out and had to be taken to hospital but the Italian later insisted he was fine.
Meanwhile, Michael Carrick is fit enough to feature against Derby, although he will not play the full 90 minutes.
Louis van Gaal tells #MUTV Darmian will miss Derby but the injury isn't too serious. Carrick may feature but won't play the full 90 minutes.
— Manchester United (@ManUtd) January 28, 2016
The news that Darmian won’t be out for too long is a boost for Man United as options at the back have worn thin in recent weeks.
Antonio Valencia recently returned to training following a lengthy absence and Marcos Rojo is stepping up his rehabilitation from a shoulder injury in Argentina. Luke Shaw, Ashley Young and Phil Jones, however, remain sidelined.
Meanwhile, Carrick’s return should mean that Marouane Fellaini’s days in central midfield are coming to an end. The Belgian has been poor in the middle of the park as of late, although he did set up the winner against Liverpool earlier this month.