The pair made first team debuts towards the latter stages of last season and have continued to feature under Jose Mourinho, making nine combined appearances in total.
They both impressed with assured displays during the 2-0 win over Swansea in the last round of the League Cup and supporters will want to see them feature once again at Ashton.
And with that in mind, here is a potential XI for the quarter-final clash with Bristol City on Wednesday night.
The return of Paul Pogba from suspension provides Mourinho with an opportunity to hand Nemanja Matic a deserved rest while seeing the Frenchman in action alongside McTominay, who has continued to make impressive steps this season.
United cannot afford to get bogged down by a lethargic midfield set-up against a Bristol side that will, no doubt, treat this as their Cup Final and stretch every sinew to make life uncomfortable for the visitors.
Supporters will hope to see a combination of Pogba’s raw brilliance and the delicate touch offered by McTominay give United a platform from which to dominate and diffuse a noisy home crowd.