The sextet were all left out of the starting XI against Valencia, although Young, Lingard and Rashford came on during the second half.
But we do know six players who will start – and none of them are exactly surprising.
Mourinho will desperately want to restore Martial to the left hand side, affording Rashford – having scored at the Mestalla on Wednesday – a chance to play down the middle instead of Romelu Lukaku, whose form has plummeted this season.
Matic and Herrera were always going to start. The big question is whether Paul Pogba will join them. Marouane Fellaini may well be preferred, or perhaps Mourinho will prefer to use a midfield pivot with wing-backs instead.